— Supporting High-Standard Compliance in the Pharmaceutical Industry

We are pleased to announce that our n-Heptane (CAS No.: 142-82-5) has successfully obtained EU REACH 1000MT+ registration, marking a significant step forward in regulatory compliance, safety, and market access. This achievement highlights our commitment to regulatory excellence and sustainable supply in the global chemical market.

Applications of n-Heptane in the Pharmaceutical Industry

In the pharmaceutical sector, n-Heptane is an essential organic solvent widely used across analysis, purification, and formulation development. Its non-polar nature and high purity make it an ideal choice in various drug manufacturing processes:

• Solvent Functions: Used for extraction, crystallization, and separation processes, particularly effective in purifying active pharmaceutical ingredients (APIs) or intermediates.
• Chromatographic Analysis: Serves as a standard solvent for gas chromatography (GC) or high-performance liquid chromatography (HPLC), facilitating accurate analysis of drug components and impurities.
• Formulation Development: Acts as an excipient or process solvent in certain formulations, assisting coating, granulation, and drying processes.
• Cleaning Agent: Suitable for cleaning equipment or glassware, especially in water-sensitive production processes.
• Reference Material: Employed in pharmacopeial testing as a standard for instrument calibration or method validation.

Significance of REACH Registration

REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) is one of the strictest chemical regulatory frameworks worldwide. Achieving 1000MT+ registration allows us to legally supply over 1,000 tons of n-Heptane annually to the EU market, backed by comprehensive physical-chemical, toxicological, and environmental assessments.

This milestone reflects our dedication to quality and regulatory compliance while strengthening our competitive edge across the pharmaceutical, coatings, rubber, ink, and specialty chemical industries.

Safety and Compliance

n-Heptane is volatile and possesses neurotoxic potential. It should be handled in well-ventilated areas with appropriate protective measures. We uphold the principles of safety, environmental responsibility, and regulatory compliance to provide customers with high-standard chemical solutions and technical support.

For technical data sheets (TDS), MSDS, or regulatory support documents related to n-Heptane, please feel free to contact us.

#Heptane #nHeptane #REACH #PharmaceuticalSolvent #GreenChemistry #ChemicalCompliance

In pharmaceutical manufacturing, purity is more than a specification — it’s a promise. Every solvent plays a critical role in ensuring product safety, consistency, and regulatory compliance. That’s why we’re proud to introduce our premium-grade n-Heptane, produced by the only REACH-registered manufacturer in China.

Why Choose Our n-Heptane

• REACH-Certified for Europe We are the sole Chinese producer of n-Heptane officially registered under the EU REACH regulation. This guarantees full compliance for import and use across European markets, including Italy.
• Pharmaceutical-Grade Purity With purity levels exceeding 99%, our n-Heptane meets the stringent requirements of pharmaceutical applications — from active ingredient extraction to crystallization and cleaning processes.
• Reliable Supply and Documentation We offer consistent production capacity, flexible packaging options, and complete technical documentation including COA and MSDS, ensuring smooth procurement and regulatory alignment.
• Dedicated Support for European Clients Our experienced export team provides clear communication, fast response times, and full assistance with logistics coordination and compliance paperwork.

Bridging Chinese Manufacturing with European Standards

Our REACH certification is more than a regulatory milestone — it’s a symbol of our long-term commitment to quality, safety, and partnership. We understand the expectations of European pharmaceutical companies and deliver accordingly.

Let’s Build a Smarter, Safer Supply Chain Together

Whether you’re optimizing your sourcing strategy or seeking a more compliant and cost-effective alternative, our n-Heptane is ready to meet your needs.

n-Heptane (CAS No.: 142-82-5) is a widely used non-polar organic solvent in pharmaceuticals, coatings, and specialty chemical industries. While its high purity and versatile applications make it an essential industrial chemical, it is important to understand its flash point, a critical property for safe handling and storage.

What is Flash Point?

The flash point of a liquid is the lowest temperature at which it can vaporize to form a combustible mixture with air. At or above this temperature, a spark or flame can ignite the vapor, potentially causing fire or explosion. Understanding flash points is fundamental for classifying chemicals, selecting storage conditions, and implementing safety measures.

Flash Point of n-Heptane

n-Heptane is highly flammable, with a flash point of approximately −4°C (24.8°F). This extremely low value indicates that n-Heptane can easily form flammable vapors at room temperature, emphasizing the need for caution during handling.

Safety Implications

Because of its low flash point, n-Heptane requires careful handling to minimize fire hazards:

• Storage: Keep in tightly sealed containers, away from heat, sparks, and open flames.
• Ventilation: Use in well-ventilated areas to prevent vapor accumulation.
• Personal Protection: Wear flame-resistant clothing and appropriate gloves and goggles.
• Grounding and Bonding: When transferring n-Heptane between containers, ensure proper grounding to avoid static sparks.

Industrial Relevance

Understanding n-Heptane’s flash point is not only important for laboratory and industrial safety but also for regulatory compliance. It helps chemical manufacturers, distributors, and end-users comply with fire safety regulations, REACH guidelines, and occupational health standards.

Conclusion

The flash point of n-Heptane is a key physical property that underscores its high flammability. Proper knowledge, storage, and handling practices ensure that this versatile solvent can be safely used in pharmaceutical, coating, and specialty chemical applications.

#nHeptane #Heptane #ChemicalSafety #FlashPoint #PharmaceuticalSolvent #FlammableLiquids #ChemicalCompliance

At Junyuan Petroleum Group’s flagship facility, our newly commissioned alkane adsorption separation unit is now delivering 99.9% ultra-high-purity n-Hexane—a pharmaceutical-grade intermediate essential for precision synthesis. Its exceptional chemical stability minimizes side reactions, enabling tighter control over drug yields and manufacturing consistency.

Since first commercializing n-Hexane with >99.6% purity in December 2006, Junyuan has continuously advanced its production capabilities. As of August 2025, we’ve become China’s first petroleum-based producer of ultra-high-purity n-Hexane, replacing imported alternatives and setting new standards for domestic chemical manufacturing.

This breakthrough reflects Junyuan’s enduring commitment to innovation in energy and fine chemicals—where purity, reliability, and performance are mission-critical.

Follow Junyuan Petroleum Group for more milestones in precision engineering and industrial excellence.

As the global chemical industry accelerates toward green transformation and intelligent manufacturing, Junyuan Petroleum Group warmly welcomes you to visit our booth at ICIF China 2025, held from September 17–19, 2025, at the Shanghai New International Expo Center.

With over two decades of expertise in high-purity hydrocarbon solvents and sulfur-based additives, Junyuan has become a trusted supplier to clients across Asia, the Middle East, Africa, and the Americas. Our flagship products include:

• n-Pentane, Iso-Pentane, Cyclopentane
• n-Hexane, Iso-Hexane, n-Heptane
• DTBPS and TBPS sulfur additives

These materials are widely used in:

• Eco-friendly blowing agents and refrigerants
• Food-grade extraction solvents (REACH-compliant)
• Petrochemical refining and catalyst systems
• Construction, coatings, pharmaceuticals, and more

Why Partner with Junyuan?

• Integrated Supply Chain: Six subsidiaries covering R&D, production, logistics, and export operations
• Global Compliance: Products certified under REACH, ISO, and other international standards
• Technical Excellence: Stable performance, high purity, and tailored formulations
• International Service: Multilingual support and customized solutions for global clients

Exhibition Dates: September 17–19, 2025 Venue: Shanghai New International Expo Center, China

Our international business team and technical consultants will be on-site to discuss your needs, explore collaboration opportunities, and share insights into the evolving chemical landscape.

We look forward to meeting you at ICIF China 2025 and building the future of chemical innovation—together.

Process Steps Explained

1. Raw Material – DCPD (Dicyclopentadiene): DCPD is commonly sourced as a byproduct from petroleum refining processes. It serves as the starting material for the production of Cyclopentane.
2. Thermal Cracking: Under high-temperature conditions, DCPD undergoes thermal cracking. This reaction breaks its molecular structure to form Cyclopentadiene, which is an unstable intermediate but necessary for the subsequent step.
3. Catalytic Hydrogenation: The Cyclopentadiene is then subjected to a catalytic hydrogenation process. In the presence of a suitable catalyst and hydrogen gas, Cyclopentadiene is converted into the stable product, Cyclopentane.
4. Final Product – Cyclopentane: Cyclopentane, the final product, is widely used as a blowing agent in the production of polyurethane foam, refrigerant insulation materials, and other applications where its distinct properties are beneficial.

Cyclopentane Production Process Flow Diagram

Below is an overview of the process used to produce Cyclopentane from DCPD.

1. Raw Material: DCPD (Dicyclopentadiene)

• Source: DCPD is typically obtained as a byproduct of petroleum refining processes. It serves as the starting material for this production route.

2. Thermal Cracking

• Process: Under high-temperature conditions, DCPD undergoes thermal cracking.
• Intermediate Result: This step converts DCPD into Cyclopentadiene, an unstable intermediate necessary for the next transformation.

3. Catalytic Hydrogenation

• Process: The Cyclopentadiene intermediate is subjected to a catalytic hydrogenation reaction.
• Outcome: With the presence of a suitable catalyst and hydrogen gas, Cyclopentadiene is converted into the final product—Cyclopentane.

Final Product: Cyclopentane

Applications

• Usage: Cyclopentane is widely utilized as a blowing agent in the production of polyurethane foam, as well as in insulation materials for refrigeration and construction applications.
• Benefits: Its favorable physical properties and environmental advantages make Cyclopentane a preferred choice in these applications.

   ┌─────────────────────────────┐  
   │ Raw Material: DCPD          │  
   │ (Dicyclopentadiene)         │  
   └─────────────────────────────┘  
                │  
                │  (Thermal Cracking)  
                ▼  
   ┌─────────────────────────────┐  
   │ Intermediate:               │  
   │ Cyclopentadiene             │  
   └─────────────────────────────┘  
                │  
                │  (Catalytic Hydrogenation)  
                ▼  
   ┌─────────────────────────────┐  
   │ Final Product:              │  
   │ Cyclopentane                │  
   └─────────────────────────────┘  

In the heart of a bustling industrial hub, where innovation meets environmental stewardship, a quiet hero plays a pivotal role in shaping the future of construction. This hero is n-Pentane, a simple yet powerful hydrocarbon that has become the backbone of eco-friendly insulation solutions and is indispensable for modern manufacturing processes.

Once overlooked in favor of less sustainable alternatives, n-Pentane emerged as a game-changer in the production of high-performance insulation panels. These panels, widely applied in areas such as cold storage, roof and wall cladding, façades, and insulated industrial doors, depend on n-Pentane to create their lightweight, energy-efficient cores. Its introduction has revolutionized the thermal insulation industry while addressing critical environmental concerns. Unlike older materials that harmed the ozone layer, n-Pentane boasts a zero ozone depletion potential (ODP), affirming its role as a key enabler of environmentally responsible manufacturing.

The story of n-Pentane begins in advanced production facilities, where it serves as an essential blowing agent in creating polyurethane and polyisocyanurate foams. These foams rely on n-Pentane to expand and form tiny bubbles, resulting in a highly effective structure for heat insulation. This process transforms raw materials into reliable products such as panels for extreme climates, significantly reducing energy use across diverse applications. Whether safeguarding perishable goods in cold storage or improving building energy efficiency, n-Pentane is at the core of sustainable solutions.

What truly sets n-Pentane apart is its remarkable ability to combine outstanding performance with environmental sustainability. It is a perfect match for manufacturers who prioritize eco-friendly initiatives and compliance with global green building standards. By contributing to modern insulated panels, n-Pentane facilitates projects that aim for both durability and environmental responsibility, reflecting its alignment with global trends in sustainable construction.

Beyond its technical applications, n-Pentane ensures smooth supply chain operations. Manufacturers worldwide depend on its reliable quality to produce top-tier insulation products on tight timelines, meeting the evolving needs of their markets and projects.

In a world increasingly committed to sustainability, n-Pentane is far more than a chemical—it is a catalyst for progress. From protecting perishable goods to improving energy efficiency in construction, it enables a future where buildings are greener, energy is conserved, and the planet is preserved. As the drive for sustainable practices continues, n-Pentane remains an essential component in shaping a world where innovation and environmental care go hand in hand.

“ GET FOAM, NOT FOMO! Foam Expo is the hub for innovation in foam technologies. We’re here showcasing our high-purity pentane solutions—essential for eco-friendly foam production and advanced thermal insulation. Let’s innovate together!

UNLOCK A YEAR OF BUSINESS OPPORTUNITIES

Foam Expo is the continent’s largest foam and adhesives supply chain event, offering three days of networking, innovation, and business growth. Explore new materials, technologies, and solutions, gain insights from conference sessions, and connect with key decision-makers at the expo. With foam and adhesives under one roof, your team can maximize opportunities and set the stage for success all year long.

How a Leader Captured 80% Heptane Market Share Through Innovation and Customer-Centric Solutions

Abstract
Junyuan Petroleum Group has emerged as the undisputed leader in the global heptane market, commanding an 80% share driven by its relentless focus on product purity, flexible packaging solutions, and unparalleled logistics infrastructure. This article explores how the company outperforms competitors to become the preferred partner for industries like pharmaceuticals, adhesives, and specialty chemicals. Key factors include its ISO-certified production, steel drum and ISO tank packaging versatility, and a global distribution network that ensures seamless delivery to over 50 countries.

Unrivaled Product Quality

Junyuan’s heptane is renowned for its ultra-high purity (99.9%+), meeting stringent standards such as USP, EP, and ASTM. Its proprietary distillation technology eliminates impurities like aromatic hydrocarbons and sulfur compounds, making it ideal for sensitive applications:

• Pharmaceuticals: Critical for drug formulation and solvent extraction, with zero tolerance for contaminants.
• Electronics Cleaning: Leaves no residue, ensuring precision in semiconductor manufacturing.
• Polymerization: Delivers consistent reactivity for high-performance polymer production.

The company’s dedicated QC labs and real-time batch tracking system guarantee compliance with client-specific requirements, earning trust from Fortune 500 manufacturers.

Packaging Flexibility: Steel Drums & ISO Tanks

Junyuan caters to diverse client needs with two optimized packaging options:

1. Steel Drums (137 kg): Ideal for small-batch orders, ensuring airtight storage and safe handling.
2. ISO Tanks (20,000+ liters): Cost-effective for bulk shipments, reducing waste and logistics costs.

Both options adhere to UN safety standards and include tamper-proof seals, minimizing risks during transit.

Global Logistics Mastery

Junyuan’s dominance stems from its integrated supply chain:

• Strategic Hubs: Warehouses in Rotterdam, Houston, Singapore, and Dubai enable rapid regional delivery.
• Pharma-Grade Logistics: Temperature-controlled ISO tanks and GDP-compliant protocols for pharmaceutical clients.
• End-to-End Tracking: Digital platforms provide real-time shipment visibility, from factory to end-user.

This infrastructure slashes lead times to 5-35 days globally, even for urgent orders.

Sticky Customers in the Pharmaceutical Sector

Junyuan’s 80% market share is anchored by long-term partnerships with top-tier pharmaceutical companies. Key drivers include:

• Regulatory Expertise: Full documentation support for FDA, REACH, and ICH guidelines.
• Customized Blends: Tailored heptane grades for tablet coating, API synthesis, and vaccine production.
• 24/7 Technical Support: On-call chemists assist with formulation challenges and process optimization.

A leading European pharma giant recently credited Junyuan’s heptane for cutting its production downtime by 30%, underscoring the value of reliability.

Why Junyuan Stands Out

• Market Leadership: 80% global heptane share, validated by independent industry reports.
• Sustainability: Closed-loop recycling programs for steel drums and ISO tanks.
• Agility: Capacity to scale production by 200% within 90 days to meet surges in demand.

Next Steps for Buyers

1. Request a Purity Audit: Validate Junyuan’s heptane against your lab specifications.
2. Optimize Costs: Leverage bulk ISO tank discounts for annual contracts.
3. Engage Regulatory Teams: Collaborate early to streamline compliance for niche applications.

Junyuan Petroleum Group’s blend of quality, innovation, and logistics precision has redefined industry benchmarks, making it the go-to heptane supplier for mission-critical applications worldwide.

Transforming Catalyst Activation in Refineries with Safer Alternatives

Abstract: Sulfiding, the process of activating hydroprocessing catalysts in refineries, traditionally relied on dimethyl disulfide (DMDS). While effective, DMDS presents safety, handling, and environmental challenges. Di-tert-butyl polysulfide (DTBPS) emerges as a superior alternative, offering increased safety due to a higher flashpoint, a less offensive odor, nonregulated transportation, and reduced SOx emissions. Pilot studies confirm that DTBPS performs on par with DMDS while enabling quicker sulfiding at lower temperatures. Despite minor differences in sulfur content, DTBPS is endorsed by catalyst manufacturers as a safer, efficient, and environmentally favorable sulfiding agent.

Keywords: Sulfiding, hydroprocessing catalysts, DTBPS, DMDS, refinery safety, SOx emissions, catalyst activation.

This article explores the key factors in the sulfiding process of hydroprocessing catalysts and their impact on catalyst performance. By analyzing the types of sulfiding agents, sulfiding conditions (e.g., temperature, pressure, time), and catalyst support properties, effective strategies for optimizing the sulfiding process are proposed. The article highlights Di-tert-butyl Polysulfide (DTBPS) as a novel sulfiding agent, which offers superior safety, lower odor, and easier transportation and storage compared to the traditional Dimethyl Disulfide (DMDS). Laboratory and industrial-scale studies demonstrate that DTBPS performs equally to DMDS in terms of sulfiding efficiency and catalyst performance, while significantly reducing environmental risks and operational costs. The article concludes with future research directions, emphasizing the need for further advancements in sulfiding technology driven by both environmental and economic benefits.

Key Terms:

• Hydroprocessing catalysts
• Sulfiding process
• Di-tert-butyl Polysulfide (DTBPS)
• Dimethyl Disulfide (DMDS)
• Catalyst performance
• Optimization strategies
• Industrial applications
• Environmental technology

Main Content

1. Importance of the Sulfiding Process

Hydroprocessing catalysts are widely used in refineries for hydrotreating, hydrodesulfurization, and hydrocracking units. Initially, catalysts are in an inert/inactive state, with active metals in oxide form. Sulfiding activates the catalyst by reacting the active metals with hydrogen sulfide, which is typically generated in situ from sulfur in the feedstock or provided by a sulfiding agent.

2. Limitations of Traditional Sulfiding Agent DMDS

Dimethyl Disulfide (DMDS) has been widely used as a sulfiding agent for many years, but it has several drawbacks:

• Safety Hazards: DMDS has a low flash point (16°C), posing fire risks during transportation, storage, and use.
• Odor Issues: DMDS has a strong, unpleasant odor, which can be a nuisance to workers and surrounding communities.
• Transportation Restrictions: Due to its low flash point, DMDS is subject to strict transportation regulations, potentially leading to additional demurrage charges.
• Environmental Emissions: The methane produced during DMDS decomposition dilutes hydrogen in the recycle gas, increasing sulfur dioxide (SOₓ) emissions.

3. Advantages of the New Sulfiding Agent DTBPS

Di-tert-butyl Polysulfide (DTBPS) is a novel sulfiding agent with the following advantages:

• Enhanced Safety: DTBPS has a high flash point (100°C), significantly reducing fire risks.
• Low Odor: DTBPS has a mild, diesel-like odor, making it more tolerable for workers and communities.
• Easier Transportation: Classified as non-hazardous, DTBPS offers greater flexibility in transportation and storage.
• Environmental Benefits: The isobutane byproduct from DTBPS decomposition does not dilute hydrogen in the recycle gas, reducing SOₓ emissions.

4. Pilot-Plant and Industrial Applications

Pilot-plant studies confirmed that DTBPS performs equally to DMDS in terms of sulfiding efficiency and catalyst performance. DTBPS decomposes at a lower temperature (160°C) compared to DMDS (200°C), allowing sulfiding to begin at lower catalyst bed temperatures. This reduces the risk of catalyst damage due to high-temperature reduction and shortens the sulfiding process time.

5. Limitations of DTBPS

DTBPS has a slightly lower sulfur content (56%) compared to DMDS (68%), requiring a slightly higher dosage to achieve the same sulfiding effect. However, this drawback is outweighed by its safety, environmental benefits, and operational convenience.

6. Industry Acceptance and Future Outlook

DTBPS has been tested and approved by major catalyst manufacturers worldwide as a safe and efficient alternative to DMDS. As environmental regulations become stricter, DTBPS is expected to gain broader adoption in the refining industry.

Tables and Figures

• Table 1: Comparison of DMDS and DTBPS Sulfiding Methods
• DTBPS:
• Low odor and high flashpoint (212°F/100°C): Safer to handle with reduced fire risk, allowing for nonregulated transport.
• Low decomposition temperature (320°F/160°C): Provides a better safety margin for catalyst reduction.
• Industry acceptance: Rapidly gaining global market share and approved by catalyst manufacturers.
• Efficiency: Sulfiding process completes in 1-2 hours, which is faster than DMDS.
• DMDS:
• Strong odor: Described as “decaying cabbage,” making it unpleasant for workers and communities.
• Low flashpoint (61°F/16°C): Requires Department of Transportation (DOT)-regulated transport and specialized handling.
• Moderate decomposition temperature (392°F/200°C): Standard for current industry processes.
• Industry standard: Widely recognized and approved, but the sulfiding process takes 18-36 hours, much longer compared to DTBPS.
• Table 2: Comparison of Chemical and Physical Properties of DMDS and DTBPS
• DTBPS is a safer and more efficient alternative to DMDS in catalyst sulfiding. It offers significant advantages such as:
• Safety: A higher flashpoint and lower decomposition temperature make it safer and reduce the risks of fire.
• Environmental Impact: DTBPS minimizes SOx emissions due to its byproduct (isobutane) and prevents hydrogen dilution in the recycle gas.
• Convenience: Nonregulated transportation simplifies logistics, while low odor improves workplace conditions.
• The trade-off for DTBPS is its lower sulfur content (56% vs. DMDS’s 68%), requiring slightly more volume to achieve equivalent sulfiding.
• Pilot studies confirm DTBPS matches DMDS in catalytic activity and delivers added benefits like shorter sulfiding times (1-2 hours vs. 18-36 hours). Globally, catalyst manufacturers recognize DTBPS as an effective alternative. Overall, DTBPS’s properties make it the preferred choice for safer, faster, and environmentally favorable refinery operations.
• Additional Insights: Hydrodesulfurization Efficiency of Catalysts Sulfided with DTBPS and DMDS
• Hydrocarbon Byproducts:
  • DMDS produces methane as its hydrocarbon byproduct during sulfiding. This methane tends to accumulate in the recycle gas stream, diluting hydrogen and lowering the hydrogen partial pressure. This often requires gas purging and hydrogen makeup, leading to SOx emissions and wasted resources.
  • In contrast, DBPS generates isobutane, which exits with liquid hydrocarbons from the high-pressure separator. This prevents hydrogen dilution and reduces SOx emissions, making it a more environmentally responsible choice.
• Operational Efficiency:
  • The lower decomposition temperature of DBPS (320°F/160°C) allows sulfiding to begin at a lower catalyst bed temperature, which reduces the risks associated with catalyst overheating (exotherms). This also shortens the sulfiding time, leading to cost savings by minimizing reactor downtime.
• Global Adoption:
  • Catalyst manufacturers worldwide endorse DBPS as a viable alternative to DMDS. Its ease of use, safety advantages, and comparable effectiveness make it a promising choice for refiners aiming to optimize operations.
• Minor Considerations:
  • The slightly lower sulfur content of DBPS (54% versus 68% for DMDS) requires a marginally higher volume of DBPS to achieve the same level of catalyst sulfiding. However, this minor inconvenience is outweighed by the safety, handling, and environmental benefits.
• Conclusion:
• DBPS stands out as a safer, more environmentally friendly, and efficient alternative to DMDS in the hydroprocessing catalyst sulfiding process. Its adoption reflects a move towards greener and more sustainable practices in the refining industry. While it does require a marginally larger dosage, the overall benefits—ranging from reduced SOx emissions to simplified handling—make it a compelling choice for modern refineries.

Conclusion

DTBPS, as a novel sulfiding agent, offers significant advantages in safety, environmental performance, and operational convenience, making it an ideal replacement for traditional DMDS. Despite its slightly lower sulfur content, its overall benefits make it the preferred choice for optimizing sulfiding processes in refineries.