— Supporting High-Standard Compliance in the Pharmaceutical Industry

We are pleased to announce that our n-Heptane (CAS No.: 142-82-5) has successfully obtained EU REACH 1000MT+ registration, marking a significant step forward in regulatory compliance, safety, and market access. This achievement highlights our commitment to regulatory excellence and sustainable supply in the global chemical market.

Applications of n-Heptane in the Pharmaceutical Industry

In the pharmaceutical sector, n-Heptane is an essential organic solvent widely used across analysis, purification, and formulation development. Its non-polar nature and high purity make it an ideal choice in various drug manufacturing processes:

• Solvent Functions: Used for extraction, crystallization, and separation processes, particularly effective in purifying active pharmaceutical ingredients (APIs) or intermediates.
• Chromatographic Analysis: Serves as a standard solvent for gas chromatography (GC) or high-performance liquid chromatography (HPLC), facilitating accurate analysis of drug components and impurities.
• Formulation Development: Acts as an excipient or process solvent in certain formulations, assisting coating, granulation, and drying processes.
• Cleaning Agent: Suitable for cleaning equipment or glassware, especially in water-sensitive production processes.
• Reference Material: Employed in pharmacopeial testing as a standard for instrument calibration or method validation.

Significance of REACH Registration

REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) is one of the strictest chemical regulatory frameworks worldwide. Achieving 1000MT+ registration allows us to legally supply over 1,000 tons of n-Heptane annually to the EU market, backed by comprehensive physical-chemical, toxicological, and environmental assessments.

This milestone reflects our dedication to quality and regulatory compliance while strengthening our competitive edge across the pharmaceutical, coatings, rubber, ink, and specialty chemical industries.

Safety and Compliance

n-Heptane is volatile and possesses neurotoxic potential. It should be handled in well-ventilated areas with appropriate protective measures. We uphold the principles of safety, environmental responsibility, and regulatory compliance to provide customers with high-standard chemical solutions and technical support.

For technical data sheets (TDS), MSDS, or regulatory support documents related to n-Heptane, please feel free to contact us.

#Heptane #nHeptane #REACH #PharmaceuticalSolvent #GreenChemistry #ChemicalCompliance

In pharmaceutical manufacturing, purity is more than a specification — it’s a promise. Every solvent plays a critical role in ensuring product safety, consistency, and regulatory compliance. That’s why we’re proud to introduce our premium-grade n-Heptane, produced by the only REACH-registered manufacturer in China.

Why Choose Our n-Heptane

• REACH-Certified for Europe We are the sole Chinese producer of n-Heptane officially registered under the EU REACH regulation. This guarantees full compliance for import and use across European markets, including Italy.
• Pharmaceutical-Grade Purity With purity levels exceeding 99%, our n-Heptane meets the stringent requirements of pharmaceutical applications — from active ingredient extraction to crystallization and cleaning processes.
• Reliable Supply and Documentation We offer consistent production capacity, flexible packaging options, and complete technical documentation including COA and MSDS, ensuring smooth procurement and regulatory alignment.
• Dedicated Support for European Clients Our experienced export team provides clear communication, fast response times, and full assistance with logistics coordination and compliance paperwork.

Bridging Chinese Manufacturing with European Standards

Our REACH certification is more than a regulatory milestone — it’s a symbol of our long-term commitment to quality, safety, and partnership. We understand the expectations of European pharmaceutical companies and deliver accordingly.

Let’s Build a Smarter, Safer Supply Chain Together

Whether you’re optimizing your sourcing strategy or seeking a more compliant and cost-effective alternative, our n-Heptane is ready to meet your needs.

n-Heptane (CAS No.: 142-82-5) is a widely used non-polar organic solvent in pharmaceuticals, coatings, and specialty chemical industries. While its high purity and versatile applications make it an essential industrial chemical, it is important to understand its flash point, a critical property for safe handling and storage.

What is Flash Point?

The flash point of a liquid is the lowest temperature at which it can vaporize to form a combustible mixture with air. At or above this temperature, a spark or flame can ignite the vapor, potentially causing fire or explosion. Understanding flash points is fundamental for classifying chemicals, selecting storage conditions, and implementing safety measures.

Flash Point of n-Heptane

n-Heptane is highly flammable, with a flash point of approximately −4°C (24.8°F). This extremely low value indicates that n-Heptane can easily form flammable vapors at room temperature, emphasizing the need for caution during handling.

Safety Implications

Because of its low flash point, n-Heptane requires careful handling to minimize fire hazards:

• Storage: Keep in tightly sealed containers, away from heat, sparks, and open flames.
• Ventilation: Use in well-ventilated areas to prevent vapor accumulation.
• Personal Protection: Wear flame-resistant clothing and appropriate gloves and goggles.
• Grounding and Bonding: When transferring n-Heptane between containers, ensure proper grounding to avoid static sparks.

Industrial Relevance

Understanding n-Heptane’s flash point is not only important for laboratory and industrial safety but also for regulatory compliance. It helps chemical manufacturers, distributors, and end-users comply with fire safety regulations, REACH guidelines, and occupational health standards.

Conclusion

The flash point of n-Heptane is a key physical property that underscores its high flammability. Proper knowledge, storage, and handling practices ensure that this versatile solvent can be safely used in pharmaceutical, coating, and specialty chemical applications.

#nHeptane #Heptane #ChemicalSafety #FlashPoint #PharmaceuticalSolvent #FlammableLiquids #ChemicalCompliance

At Junyuan Petroleum Group’s flagship facility, our newly commissioned alkane adsorption separation unit is now delivering 99.9% ultra-high-purity n-Hexane—a pharmaceutical-grade intermediate essential for precision synthesis. Its exceptional chemical stability minimizes side reactions, enabling tighter control over drug yields and manufacturing consistency.

Since first commercializing n-Hexane with >99.6% purity in December 2006, Junyuan has continuously advanced its production capabilities. As of August 2025, we’ve become China’s first petroleum-based producer of ultra-high-purity n-Hexane, replacing imported alternatives and setting new standards for domestic chemical manufacturing.

This breakthrough reflects Junyuan’s enduring commitment to innovation in energy and fine chemicals—where purity, reliability, and performance are mission-critical.

Follow Junyuan Petroleum Group for more milestones in precision engineering and industrial excellence.

As the global chemical industry accelerates toward green transformation and intelligent manufacturing, Junyuan Petroleum Group warmly welcomes you to visit our booth at ICIF China 2025, held from September 17–19, 2025, at the Shanghai New International Expo Center.

With over two decades of expertise in high-purity hydrocarbon solvents and sulfur-based additives, Junyuan has become a trusted supplier to clients across Asia, the Middle East, Africa, and the Americas. Our flagship products include:

• n-Pentane, Iso-Pentane, Cyclopentane
• n-Hexane, Iso-Hexane, n-Heptane
• DTBPS and TBPS sulfur additives

These materials are widely used in:

• Eco-friendly blowing agents and refrigerants
• Food-grade extraction solvents (REACH-compliant)
• Petrochemical refining and catalyst systems
• Construction, coatings, pharmaceuticals, and more

Why Partner with Junyuan?

• Integrated Supply Chain: Six subsidiaries covering R&D, production, logistics, and export operations
• Global Compliance: Products certified under REACH, ISO, and other international standards
• Technical Excellence: Stable performance, high purity, and tailored formulations
• International Service: Multilingual support and customized solutions for global clients

Exhibition Dates: September 17–19, 2025 Venue: Shanghai New International Expo Center, China

Our international business team and technical consultants will be on-site to discuss your needs, explore collaboration opportunities, and share insights into the evolving chemical landscape.

We look forward to meeting you at ICIF China 2025 and building the future of chemical innovation—together.

High-Purity n-Hexane: A Competitive Edge Driven by Hydrogen Innovation

In the world of industrial chemistry, n-hexane (C₆H₁₄) plays a vital role as a solvent and intermediate—used in everything from edible oil extraction and rubber synthesis to precision laboratory analysis. Yet behind its seemingly simple molecular structure lies a complex challenge: how to transform crude n-hexane, often laden with sulfur compounds, olefins, aromatics, and trace metals, into a high-purity product that meets the demands of food, pharmaceutical, and electronics-grade applications.

The answer? A cutting-edge solution known as hydrogen refining—a molecular-level purification journey powered by precision chemistry and sustainable innovation.

The Hidden Impurities: Why Crude n-Hexane Needs Refining

Crude n-hexane derived from petroleum cracking contains a cocktail of unwanted guests:

• Reactive olefins like 1-hexene and cyclohexene, prone to side reactions
• Sulfur compounds such as carbon disulfide and mercaptans, corrosive and odorous
• Aromatic hydrocarbons like benzene and toluene, which pose safety risks
• Trace metals from catalysts and equipment wear, compromising product stability

These impurities degrade solvent performance, increase volatility, and may release toxic byproducts during use. Purity isn’t just a preference—it’s a necessity.

Hydrogen Refining: A Two-Stage Molecular Purification

Hydrogen refining uses H₂ gas and advanced catalysts to chemically transform impurities into stable, separable compounds. The process unfolds in two meticulously controlled stages:

Stage 1: Targeted Removal of Reactive Impurities

Under high temperature (200–400°C) and pressure (5–10 MPa), crude n-hexane reacts with excess hydrogen in a fixed-bed reactor. Catalysts like Co-Mo or Ni-Mo on alumina initiate:

• Olefin saturation: Double bonds convert to single bonds, stabilizing the molecule
• Desulfurization: Sulfur bonds break, forming hydrogen sulfide (H₂S)
• Denitrogenation and deoxygenation: Nitrogen and oxygen impurities become ammonia (NH₃) and water

This stage removes over 90% of active contaminants.

Stage 2: Deep Purification with Noble Metals

The partially refined product enters a second reactor at even higher conditions (300–450°C, 10–15 MPa), where platinum or palladium catalysts deliver:

• Aromatic hydrogenation: Benzene rings convert to cyclohexane, eliminating carcinogenic risks
• Ultra-trace sulfur removal: Sulfur levels drop to ppb (parts per billion)
• Metal ion capture: Catalyst surfaces adsorb residual heavy metals

The result? n-Hexane with >99.5% purity, meeting stringent standards for sensitive applications.

Smart Refining: Precision Meets Sustainability

Modern hydrogen refining systems integrate advanced technologies:

• Infrared temperature sensors for real-time reactor monitoring
• Membrane-based hydrogen recycling, achieving >95% reuse
• Catalyst regeneration via controlled oxygen burn-off, extending life to 3–5 years
• Online mass spectrometry for automatic process optimization

These innovations enable annual throughput exceeding 100,000 tons per unit, while reducing energy use by 20% and carbon emissions by 15%.

A Green Chemistry Breakthrough

Compared to traditional acid washing or distillation, hydrogen refining offers clear environmental advantages:

• Zero liquid waste: Byproducts like H₂S are recycled into elemental sulfur
• Low VOC emissions: Closed systems minimize solvent loss
• Energy recovery: Reaction heat is converted into steam for other plant operations

Each ton of high-purity n-hexane produced via hydrogen refining cuts CO₂ emissions by 1.2 tons—equivalent to planting 65 fir trees.

The Future: Nano Catalysts and AI Optimization

As material science advances, hydrogen refining is entering a new era:

• Single-atom catalysts boost active sites tenfold, maximizing efficiency
• Machine learning models optimize reaction kinetics and process parameters
• Modular reactor designs offer scalable solutions for SMEs and remote facilities

From petrochemicals to semiconductors, edible oils to pharmaceuticals, the demand for ultra-pure n-hexane is rising. Hydrogen refining isn’t just a technical upgrade—it’s a strategic leap toward cleaner, smarter, and more sustainable chemical manufacturing.

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Junyuan Petroleum Group, China’s largest n-Pentane producer, has successfully achieved continuous exports for the 19th consecutive year. Recently, 260 tons of n-Pentane were shipped from Qingdao Port to Colombia, marking another solid step in the company’s steady expansion into international markets.

Over the past years, Junyuan has actively promoted the transformation and upgrading of the petrochemical industry by relying on advanced naphtha chemical technology. Its products not only hold a strong position in the domestic market but also represent a leap from “Made in China” to “Global Solutions.” Through in-depth market research and front-line engagement, Junyuan has strategically targeted regions such as Southeast Asia and South America. By collaborating with major domestic trading partners, participating in international exhibitions, and opening up trade channels along the Belt and Road, the company has significantly expanded the global reach of its n-Pentane products.

In Colombia, particularly in the port cities of Buenaventura and Cartagena, n-Pentane plays a vital role:

Blowing Agent in polyurethane (PU) and polystyrene (EPS) foams, essential for insulation in refrigerators and construction panels.

Organic Solvent in adhesives, coatings, and inks.

Electronics Cleaning Agent to remove grease and impurities in manufacturing processes.

Refrigerant Component (R601) in eco-friendly cooling systems.

Chemical Intermediate, Laboratory Applications, and Specialty Uses in fine chemicals, chromatography, and performance-enhancing materials.

With its “Terminal + Internationalization” dual-driven strategy, Junyuan has built a strong supply chain that ensures reliable delivery through ISO tanks and customized packaging solutions. The company’s efforts are also aligned with the high-level development of inland open economy pilot zones in China, while strengthening long-term cooperation with international partners.

A company spokesperson emphasized that exporting to Colombia is an important milestone in Junyuan’s international strategy. Looking ahead, Junyuan will continue to explore overseas market potential, expand export volumes, and enhance the global recognition of its brand concept — “Junyuan · More than n-Pentane.” By doing so, Junyuan Petroleum Group aims to bring more high-quality naphtha-based chemical products to the global stage and contribute to the growing recognition of Chinese manufacturing worldwide.

Two Essential Blowing Agents: Cyclopentane and Pentane

In the world of insulation and polymer manufacturing, blowing agents play a critical role in creating lightweight, energy-efficient materials. Among the most widely used are cyclopentane and pentane, both hydrocarbon compounds known for their effectiveness and environmental advantages. Let’s explore their properties and applications.

Cyclopentane: Properties and Applications

Physical and Chemical Characteristics

Cyclopentane is a colorless, highly volatile liquid with a distinct gasoline-like odor. Key properties include:

• Freezing Point: –94°C
• Boiling Point: ~49°C
• Vapor Density: 2.4 times that of air
• Vapor Pressure: 36.6 kPa at 20°C; 69 kPa at 38°C
• Density (20°C): 0.745 g/cm³
• Flash Point (closed cup): –37°C (Highly flammable)
• Autoignition Temperature: 361°C
• Explosion Limits (vol%): 1.5% – 8.7%
• Occupational Exposure Limit (TLV/TWA): 600 ppm

Technical Specifications

Commercial-grade cyclopentane typically meets the following standards:

• Appearance: Clear, colorless liquid with no suspended solids
• Purity: ≥99%
• Moisture Content: <50 ppm
• Non-volatile Residue: <10 ppm
• Acidity: Neutral, free of acidic substances

Application Highlights

Cyclopentane is prized for its zero ozone depletion potential (ODP) and zero global warming potential (GWP), making it an ideal replacement for CFC-11 in foam production. It is commonly used in:

1. CFC-free refrigerators and freezers
2. Cold storage insulation systems
3. Pipeline thermal insulation

Usage Notes

• Cyclopentane has limited solubility in polyether polyols, so low-viscosity polyols are preferred.
• It can be blended with isopentane to optimize performance.

Pentane: Properties and Applications

Pentane refers to a group of isomers, primarily n-pentane and isopentane, both used in industrial applications.

Physical and Chemical Characteristics

At room temperature, pentane is a clear, colorless liquid with a faint aromatic odor. It is:

• Free of olefins
• Free of suspended solids and water

Technical Specifications

Typical industrial-grade pentane meets the following criteria:

• Appearance: Clear, no sediment or haze
• Purity: ≥99% for n-pentane; ≥98% for isopentane
• Composition: n-pentane is rich in straight-chain alkanes; isopentane contains branched isomers
• Moisture Content: <20 ppm
• Sulfur Content: <1 ppm
• Bromine Index: Low (indicates minimal unsaturated hydrocarbons)

Application Highlights

Pentane is derived from efficient distillation of light hydrocarbons from oil fields. Its main uses include:

1. Desorption agent in molecular sieve dewaxing (n-pentane)
2. Blowing agent for expandable polystyrene (EPS) — often a blend of n- and isopentane
3. Polyurethane foam production, often in combination with cyclopentane

Environmental and Industrial Relevance

Both cyclopentane and pentane are vital in the shift toward eco-friendly insulation materials. Their low environmental impact and high efficiency make them indispensable in modern manufacturing, especially as industries move away from ozone-depleting substances.

Global n-Hexane Market Transformation: Junyuan Petroleum Group Leads the Charge in Sustainable Innovation and High-Purity Solutions

1. Market Overview & Growth Drivers

Amid surging demand for bio-based materials, the global n-hexane market is entering a transformative phase. In 2023, the market reached USD 1.24 billion and is projected to exceed USD 1.98 billion by 2032, growing at a CAGR of 5.83%. This expansion is fueled by three key forces:

• The electric vehicle boom driving lithium battery separator production
• Expansion of softgel capsule capacity in the pharmaceutical sector
• Widespread adoption of sustainable vegetable oil extraction technologies

2. Technological Breakthroughs & Environmental Innovation

Leading players are accelerating innovation across the value chain:

• Closed-loop recovery systems: Boosting n-hexane recovery rates from 60% to 92%
• Bio-based n-hexane: Corn starch fermentation reduces carbon footprint by 40%
• Nano-level purification: Elevating pharmaceutical-grade purity to 99.99%
• Smart monitoring devices: Real-time solvent residue detection ensures food safety

3. Regional Market Dynamics

Asia-Pacific (41% market share):

• China’s edible oil capacity grows 8% annually, driving extraction demand
• India surpasses 200 FDA-certified pharmaceutical manufacturers
• Japan’s imports of electronic-grade n-hexane rise by 15%

North America (fastest growth):

• $42 billion battery investment spurred by the Inflation Reduction Act
• Food-grade n-hexane prices up 23% since 2020
• Canada’s biodiesel policies create new demand streams

4. Application Landscape

Extraction (54% share):

• Supercritical CO₂ + n-hexane hybrid extraction improves efficiency by 35%
• Soybean oil residue reduced to 0.8 ppm
• USDA regulations promote non-GMO certification

Industrial Solvents (38% share):

• Specialized formulations for EV motor cleaning
• Biodegradable adhesive base for sustainable packaging
• Precision cleaning solutions for microelectronic components

5. Competitive Landscape & Strategic Moves

Junyuan Petroleum Group has emerged as the undisputed leader in the global n-hexane market, setting benchmarks in pharmaceutical-grade production and sustainable innovation. Key strategic developments include:

Junyuan’s commitment to R&D and quality has positioned it as the go-to supplier for high-purity, compliant n-hexane across Asia, Europe, and North America.

6. Regulatory & Standards Evolution

• FDA updates on food contact material standards
• EU REACH introduces new emission restrictions
• China enforces GB 1886.291-2023 national standard

Certification Trends:

• ISO 15338 certification for pharmaceutical-grade solvents
• Rising demand for Kosher-certified food-grade n-hexane
• ESG ratings increasingly influence procurement decisions

7. Future Outlook & Emerging Trends

Technology Integration:

• AI-driven distillation optimization
• Blockchain-based supply chain traceability
• Membrane separation to reduce energy consumption

New Applications:

• Solid-state electrolyte production
• Solvent systems for mRNA vaccine delivery
• Support materials for 3D printing

8. Risks & Challenges

• Raw material volatility: Crude oil price fluctuations impact cost structures
• Substitution threat: Accelerated R&D in ionic liquid solvents
• Overcapacity risk: 300,000 tons of new capacity expected by 2025

Industry Insight

The global n-hexane market is undergoing a strategic shift—from traditional solvent applications to high-value, specialized uses. With Junyuan Petroleum Group leading the charge in pharmaceutical-grade innovation and bio-based production, the next five years will be defined by:

• High-end applications reaching 35% of total market share
• Bio-based products exceeding 15% penetration
• Smart chemical plants achieving over 40% adoption

Junyuan’s foresight, technical excellence, and global partnerships continue to shape the future of n-hexane—making it not just a supplier, but a strategic architect of the industry’s evolution.

Keywords: n-Hexane, n-Heptane, Isohexane, CAS Number, HS Code, UN Number, Applications, Chemical Properties, Industrial Use

Abstract

This article provides a comparative analysis of n-Hexane, n-Heptane, and Isohexane in terms of their CAS numbers, HS codes, UN numbers, and practical applications. These hydrocarbons play crucial roles in industrial solvents, fuel additives, and chemical synthesis. Understanding their regulatory classifications and primary uses enables better decision-making in logistics, trade, and compliance.

Introduction

n-Hexane, n-Heptane, and Isohexane are key hydrocarbons used in various industrial applications, particularly in solvent extraction, chemical synthesis, and fuel formulation. While they share similar structures, their distinct properties define their applications and regulatory classifications.

Chemical Identifiers and Classification

Each compound has a unique CAS number, which serves as an international identifier in chemical databases. Their HS codes categorize them for international trade purposes, ensuring standardized tariffs and trade policies. The UN numbers indicate transportation hazards and are used for classifying hazardous materials under shipping regulations.

Applications

1. n-Hexane

• Widely used as a solvent in industrial processes such as oil extraction, adhesives, and coatings.
• Commonly found in degreasing agents due to its strong solvency properties.
• Frequently used in laboratory settings for chromatography and chemical synthesis.

2. n-Heptane

• Applied in octane rating determination for fuels, particularly in gasoline standardization.
• Used as a non-polar solvent in chemical and pharmaceutical industries.
• Functions as a cleaning agent for electronics and specialized machinery.

3. Isohexane

• Primarily utilized in gasoline blending as a high-performance fuel component.
• Used in polymer manufacturing and synthetic rubber production.
• Commonly found in formulations requiring controlled volatility characteristics.

Conclusion

n-Hexane, n-Heptane, and Isohexane serve distinct roles in industrial applications, yet share common classifications for trade and regulatory purposes. Understanding their CAS numbers, HS codes, and UN numbers aids in navigating logistics and compliance requirements efficiently. The diverse applications of these hydrocarbons reinforce their significance in industries such as fuel refining, chemical processing, and manufacturing.