Description

Dimethyl Sulfoxide is a highly polar organic liquid that is used widely as a chemical solvent and a free radical scavenger. Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO.

DIMETHYL SULFOXIDE
CAS#: 67-68-5
FOOD GRADE: No
ORGANIC: No
MARKET: Metal Finishing / Electroplating
CLASS (APPLICATION): SOLVENTS/CLEANERS
Molecular Formula: C2H6OS
Molecular Weight (g/mol): 78.13
InChI Key: IAZDPXIOMUYVGZ-UHFFFAOYSA-NShow
Synonym: dimethyl sulfoxide, dmso, methyl sulfoxide, dimethylsulfoxide, dimethyl sulphoxide, methane, sulfinylbis, demsodrox, demasorb, demavet, dimexideShow Less
SMILES: CS(C)=O

Dimethyl sulfoxide

MDL: MFCD00002089

EINECS: 200-664-3

Chemical Properties

Formula: C₂H₆OS

Formula Weight: 78.13

Form: Clear, colorless Liquid

Melting point: 18.4°

Boiling Point: 189°

Flash Point: 87°(189°F)

Density: 1.101

Refractive Index: 1.4790

Storage & Sensitivity: Hygroscopic. Ambient temperatures.

Solubility: Miscible with water, diethyl ether, ethanol, acetone, ether, carbon tetrachloride and ethyl acetate.

Grade Specifications

Maximum level of impurities: Evaporation residue 0.01%, Titratable acid 0.001meq/g, H₂O 0.1%

Applications

It is used as a solvent for chemical reactions involving salts, most notably in Finkelstein reactions and in other nucleophilic substitutions. Used in antifreeze or hydraulic fluids. Utilized in the oxidation of thiols and disulfides to sulfonic acids.

Notes

It is a hygroscopic liquid. It should be stored away from oxidizing agents such as heat or other ignition sources.

GHS Hazard and Precautionary Statements

Hazard Statements: H227

Combustible liquid.

Precautionary Statements: P210-P403+P235-P501c

Keep away from heat/sparks/open flames/hot surfaces. – No smoking. Store in a well-ventilated place. Keep cool. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck: 14,3259

Beilstein: 506008

Harmonized Tariff Code: 2930.90

TSCA: Yes

RTECS: PV6210000

Dimethyl Sulphoxide (DMSO)

Molecular Formula : C2H6SO
Molecular Weight : 78.13
Storage : Room Temperature
Shelf Life : 60 Months
HSN Code : 29309099
IMDG Identification :Not Regulated for Transport (Non-Haz)

Specifications

Appearance (Clarity)	Clear
Appearance (Colour)	Colourless
Appearance (Form)	Liquid
Colour (APHA)	max. 10
Assay (GC)	min. 99.5%
Density (g/ml) @ 20°C	1.099-1.101
Refractive Index (20°C)	1.478-1.479
Boiling Range	189-192°C
Freezing Point	17-18°C
Non Volatile Matter	max. 0.002%
Acidity (CH3COOH)	max. 0.001%
Iron (Fe)	max. 0.00005%
Substance Discoloured by H2SO4	Passes test
Heavy Metals (Pb)	max. 0.0001%
Copper (Cu)	max. 0.00005%
Water (KF)	max. 0.03%

Chemical name:	DMSO
CAS Number:	67-68-5
Synonyms:	Dimethyl sulfoxide (EP/BP); Sulfinylbismethane; Methyl Sulfoxide; DMS 70; DMS 90; DMSO Evol; Demasorb; Demavet; Demeso; Demsodrox; Dimethyl Sulphoxide; Dimethylsulfoxide; Dimexide; Dimexidum; Dipirartril-tropico; Dolicur; Domoso; Dromisol; Durasorb; Gamasol 90; Herpid; Hyadur; Infiltrina; Kemsol; Rimso 50; SQ 9453; Sclerosol; Somipront; Sulfinylbismethane; Syntexan;
Molecular form:	C₂H₆OS
Appearance:	Clear Colourless Oil
Mol. Weight:	78.13
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient

Physical

Form: liquid
Colour: colourless
Melting point: 18.5°C
Boiling point: 189°C
Flash point: 95°C

Density: 1,10 g/ml
Mol Weight: 78.13 g/mol
Storage temp: RT

Specs

Assay >99%
Non Volatiles <0.001%
Water <0.2%
Free Acid <0.001%
Colour < 10 APHA
Total Organic Impurities < 0.02%
Absorbance Ratio @ 285/275nm <0.65
Absorbance Ratio @ 295/275nm <0.45
Absorbance @ 270 to 350nm : passes test

Product Description

Dimethyl Sulfoxide is commonly used as an important polar aprotic solvent.

Specification

Purity: ≥99.9%

Appearance: Clear Colourless Liquid

Synonyms: DMSO; Somipront; Sulfinylbismethane; Syntexan

Solubility: Soluble in chloroform, methanol, water.

Storage: Freezer

Properties

Boiling Point: 189 °C (lit.)

Melting Point: 16-19 °C (lit.)

Density: 1.10 g/mL (lit.)

InChI Key: IAZDPXIOMUYVGZ-UHFFFAOYSA-N

InChI: InChI=1S/C2H6OS/c1-4(2)3/h1-2H3

Canonical SMILES: CS(=O)C

Refractive Index: n20/D 1.479 (lit.)

Stability: Stable. Incompatible with a very wide range of materials, including acid chlorides, strong acids, strong oxidizing agents, strong reducing agents, phosphorus halides, moisture, copper wool + trichloroacetic acid. Reacts violently with a number of materials

Dimethyl Sulfoxide – DMSO

CAS No: 67-68-5

Packing: Drums, IBCs, ISO-tank

Delivery promt form storage Dongying

Physical Properties:

Appearance:	colorless clear liquid (est)
Assay:	99.00 to 100.00
Food Chemicals Codex Listed:	No
Specific Gravity:	1.08700 to 1.09200 @ 25.00 °C.
Pounds per Gallon – (est).:	9.045 to 9.087
Refractive Index:	1.46900 to 1.48000 @ 20.00 °C.
Melting Point:	17.00 to 19.00 °C. @ 760.00 mm Hg
Boiling Point:	189.00 to 190.00 °C. @ 760.00 mm Hg
Vapor Pressure:	0.610000 mmHg @ 25.00 °C.
Vapor Density:	2.7 ( Air = 1 )
Flash Point:	183.00 °F. TCC ( 83.89 °C. )
logP (o/w):	-1.350
Soluble in:
	alcohol
	oil
	water, 1e+006 mg/L @ 25 °C (est)

Product Specification

	Refractive Index			1.470-1.480
	Colour			≤30 APHA
	Water Content			≤0.1%
	Purity			≥99.5%
	Acidity			≤ 0.05mg KOH/g
	Crystallization point			≥18.1°C
	Appearance			Clear colourless liquid
	For research use only, not for human use			For research use only, not for human use

Specifications

Appearance	White or Colorless to Almost white or Almost colorless powder to lump to clear liquid
Purity(GC)	min. 99.0 %

Properties (reference)

Melting Point	18 °C
Boiling Point	189 °C
Flash point	95 °C
Specific Gravity (20/20)	1.10
Refractive Index	1.48
Solubility in water	Completely miscible
Solubility (miscible with)	Ethanol,Chloroform,Acetone,Benzene,Ether

Application

Chlorination of (Hetero)arene Derivatives with DMSO Catalyst

References

DMSO-catalysed late-stage chlorination of (hetero)arenes
- S. Song, X. Li, J. Wei, W. Wang, Y. Zhang, L. Ai, Y. Zhu, X. Shi, X. Zhang, N. Jiao, Nat. Catal. 2020, 3, 107.
Regioselective copper-catalyzed chlorination and bromination of arenes with O₂ as the oxidant
- L. Yang, Z. Lu, S. S. Stahl, Chem. Commun. 2009, 6460.
Para-Selective Halogenation of Nitrosoarenes with Copper(II) Halides
- A. van der Werf, N. Selander, Org. Lett. 2015, 17, 6210.

Description
Catalogue Number	109678
Synonyms	Methanesulfinylmethane, Methyl sulfoxide, Dimethyl(oxido)sulfur, DMSO
Description	Dimethyl sulfoxide

Product Information
CAS number	67-68-5
EC number	200-664-3
Hill Formula	C₂H₆OS
Chemical formula	(CH₃)₂SO
Molar Mass	78.13 g/mol
HS Code	2930 90 98
Structure formula Image
Quality Level	MQ100

Applications
Application	Dimethyl sulfoxide for gas chromatography. CAS 67-68-5, chemical formula (CH₃)₂SO.

Physicochemical Information
Boiling point	189 °C (1013 hPa)
Density	1.1 g/cm3 (20 °C)
Explosion limit	1.8 – 63.0 %(V)
Flash point	87 °C
Ignition temperature	300 – 302 °C
Melting Point	18.5 °C
Saturation concentration (air)	8.0 g/m3 (20 °C)
Vapor pressure	0.55 hPa (20 °C)
Viscosity kinematic	2.14 mm2/s
Solubility	1000 g/l

Toxicological Information
LD 50 oral	LD50 Rat 28300 mg/kg
LD 50 dermal	LD50 Rat 40000 mg/kg

Safety Information according to GHS
RTECS	PV6210000
Storage class	10 – 13 Other liquids and solids
WGK	WGK 1 slightly hazardous to water
Disposal	1 Strongly contaminated halogen-free organic solvents: container A.

Storage and Shipping Information
Storage	Store at +2°C to +30°C.

Transport Information
Declaration (railroad and road) ADR, RID	Kein Gefahrgut
Declaration (transport by air) IATA-DGR	No Dangerous Good
Declaration (transport by sea) IMDG-Code	No Dangerous Good

Specifications
Assay (GC)	≥ 99.7 %
Identity (IR)	conforms
Water	≤ 0.3 %

Dimethyl Sulfoxide (DMSO) is a solvent with wide ranging applications in biological research. Dimethyl Sulfoxide (DMSO) can be used as solvent for acetylene, sulfur dioxide and other gases, as an anti-freeze or hydraulic fluid when mixed with water, as a paint or varnish remover and as a solvent for Orlon and other synthetic fibres. Dimethyl Sulfoxide (DMSO) is also used for polymerization and cyanide reactions and in industrial cleaners, pesticides, medicine (anti-inflammatory), veterinary medicine and pharmaceuticals. Dimethyl Sulfoxide (DMSO) (1-10%) has been shown to accelerate strand renaturation and is believed to give the nucleic acid thermal stability against depurination. As a PCR cosolvent, Dimethyl Sulfoxide (DMSO) may help improve yields, especially in long PCR. Dimethyl Sulfoxide is also known as DMSO, Methyl sulfoxide, Dimethyl sulphoxide, and Methylsulfinylmethane.

References

1. Sweat, F.W. and Epstein, W.W. 1967. J. Org. Chem. 32(3): 835-838. PMID: 6042131

2. Chakrabarti, R. and Schutt, C.E. 2001. Gene. 274(1-2): 293-298. PMID: 11675022

3. Pegg, D.E. 2007. Methods Mol. Biol. 368 : 39-57. PMID: 18080461

Usage :

To prepare a sterile filtered DMSO solution, it is recommended to use a teflon or nylon membrane. Cellulose acetate membranes are not recommended

Appearance : Clear, colorless liquid

Physical State :Liquid

Solubility :Soluble in water, ethanol, ether, benzene, chloroform, and acetone.

Storage :Store at room temperature

Melting Point :16-19° C

Boiling Point :189° C

Density :1.10 g/mL

Refractive Index :n²⁰_D 1.48 (lit.)

IC50 :HII4E cells : IC₅₀ = 199 µg/ml (mouse)

Ki Data :Choline acetylase: K_i= 25000000 nM (Rattus norvegicus)

pK Values :pK_a: -4.54

WGK Germany :1
RTECS :PV6210000
PubChem CID :679
Merck Index :14: 3259
MDL Number :MFCD00002089
EC Number :200-664-3
Beilstein Registry :506008
SMILES :CS(=O)C

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Dimethyl Sulfoxide