Dimethyl Sulfoxide
Dimethylsulfoxide, or DMSO, is a polar organic solvent for both organic and inorganic chemicals. It is most often used to solubilize peptides for PCR, NMR spectroscopy, DNA sequencing, affinity chromatography, as well as transformation and transfection protocols. DMSO has even been used as a cryoprotectant in cell freezing media.
- CAS: 67-68-5
- Synonym: dimethyl sulfoxide, dmso, methyl sulfoxide, dimethylsulfoxide, dimethyl sulphoxide, methane, sulfinylbis, demsodrox, demasorb, demavet, dimexide
- Percent Purity: ≥99.9%
- Molecular Formula: C2H6OS
- Molecular Weight (g/mol): 78.13
- Physical Form: Liquid
Description
Dimethyl Sulfoxide is a highly polar organic liquid that is used widely as a chemical solvent and a free radical scavenger. Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO.
DIMETHYL SULFOXIDE
CAS#: 67-68-5
FOOD GRADE: No
ORGANIC: No
MARKET: Metal Finishing / Electroplating
CLASS (APPLICATION): SOLVENTS/CLEANERS
Molecular Formula: C2H6OS
Molecular Weight (g/mol): 78.13
InChI Key: IAZDPXIOMUYVGZ-UHFFFAOYSA-NShow
Synonym: dimethyl sulfoxide, dmso, methyl sulfoxide, dimethylsulfoxide, dimethyl sulphoxide, methane, sulfinylbis, demsodrox, demasorb, demavet, dimexideShow Less
SMILES: CS(C)=O
Dimethyl sulfoxide
Chemical Properties
Grade Specifications
Maximum level of impurities: Evaporation residue 0.01%, Titratable acid 0.001meq/g, H2O 0.1%
Applications
It is used as a solvent for chemical reactions involving salts, most notably in Finkelstein reactions and in other nucleophilic substitutions. Used in antifreeze or hydraulic fluids. Utilized in the oxidation of thiols and disulfides to sulfonic acids.
Notes
GHS Hazard and Precautionary Statements
Hazard Statements: H227
Combustible liquid.
Precautionary Statements: P210-P403+P235-P501c
Keep away from heat/sparks/open flames/hot surfaces. – No smoking. Store in a well-ventilated place. Keep cool. Dispose of contents/ container to an approved waste disposal plant
Other References
Dimethyl Sulphoxide (DMSO)
Molecular Formula : C2H6SO
Molecular Weight : 78.13
Storage : Room Temperature
Shelf Life : 60 Months
HSN Code : 29309099
IMDG Identification :Not Regulated for Transport (Non-Haz)
| Specifications | ||||||||||||||||||||||||||||||||||
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| Chemical name: | DMSO |
| CAS Number: |
67-68-5 |
| Synonyms: |
Dimethyl sulfoxide (EP/BP); Sulfinylbismethane; Methyl Sulfoxide; DMS 70; DMS 90; DMSO Evol; Demasorb; Demavet; Demeso; Demsodrox; Dimethyl Sulphoxide; Dimethylsulfoxide; Dimexide; Dimexidum; Dipirartril-tropico; Dolicur; Domoso; Dromisol; Durasorb; Gamasol 90; Herpid; Hyadur; Infiltrina; Kemsol; Rimso 50; SQ 9453; Sclerosol; Somipront; Sulfinylbismethane; Syntexan; |
| Molecular form: | C2H6OS |
| Appearance: | Clear Colourless Oil |
| Mol. Weight: | 78.13 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
- Form: liquid
- Colour: colourless
- Melting point: 18.5°C
- Boiling point: 189°C
- Flash point: 95°C
- Density: 1,10 g/ml
- Mol Weight: 78.13 g/mol
- Storage temp: RT
- Assay >99%
- Non Volatiles <0.001%
- Water <0.2%
- Free Acid <0.001%
- Colour < 10 APHA
- Total Organic Impurities < 0.02%
- Absorbance Ratio @ 285/275nm <0.65
- Absorbance Ratio @ 295/275nm <0.45
- Absorbance @ 270 to 350nm : passes test
Product Description
Dimethyl Sulfoxide is commonly used as an important polar aprotic solvent.
Specification
Properties
Dimethyl Sulfoxide – DMSO
CAS No: 67-68-5
Packing: Drums, IBCs, ISO-tank
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.08700 to 1.09200 @ 25.00 °C. |
| Pounds per Gallon – (est).: | 9.045 to 9.087 |
| Refractive Index: | 1.46900 to 1.48000 @ 20.00 °C. |
| Melting Point: | 17.00 to 19.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 189.00 to 190.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.610000 mmHg @ 25.00 °C. |
| Vapor Density: | 2.7 ( Air = 1 ) |
| Flash Point: | 183.00 °F. TCC ( 83.89 °C. ) |
| logP (o/w): | -1.350 |
| Soluble in: | |
| alcohol | |
| oil | |
| water, 1e+006 mg/L @ 25 °C (est) | |
| Refractive Index | 1.470-1.480 | ||||
| Colour | ≤30 APHA | ||||
| Water Content | ≤0.1% | ||||
| Purity | ≥99.5% | ||||
| Acidity | ≤ 0.05mg KOH/g | ||||
| Crystallization point | ≥18.1°C | ||||
| Appearance | Clear colourless liquid | ||||
| For research use only, not for human use | For research use only, not for human use |
| Appearance | White or Colorless to Almost white or Almost colorless powder to lump to clear liquid |
| Purity(GC) | min. 99.0 % |
| Melting Point | 18 °C |
| Boiling Point | 189 °C |
| Flash point | 95 °C |
| Specific Gravity (20/20) | 1.10 |
| Refractive Index | 1.48 |
| Solubility in water | Completely miscible |
| Solubility (miscible with) | Ethanol,Chloroform,Acetone,Benzene,Ether |
References
- DMSO-catalysed late-stage chlorination of (hetero)arenes
- Regioselective copper-catalyzed chlorination and bromination of arenes with O2 as the oxidant
- Para-Selective Halogenation of Nitrosoarenes with Copper(II) Halides
| Description | |
|---|---|
| Catalogue Number | 109678 |
| Synonyms | Methanesulfinylmethane, Methyl sulfoxide, Dimethyl(oxido)sulfur, DMSO |
| Description | Dimethyl sulfoxide |
| Product Information | |
|---|---|
| CAS number | 67-68-5 |
| EC number | 200-664-3 |
| Hill Formula | C₂H₆OS |
| Chemical formula | (CH₃)₂SO |
| Molar Mass | 78.13 g/mol |
| HS Code | 2930 90 98 |
| Structure formula Image |  |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Dimethyl sulfoxide for gas chromatography. CAS 67-68-5, chemical formula (CH₃)₂SO. |
| Physicochemical Information | |
|---|---|
| Boiling point | 189 °C (1013 hPa) |
| Density | 1.1 g/cm3 (20 °C) |
| Explosion limit | 1.8 – 63.0 %(V) |
| Flash point | 87 °C |
| Ignition temperature | 300 – 302 °C |
| Melting Point | 18.5 °C |
| Saturation concentration (air) | 8.0 g/m3 (20 °C) |
| Vapor pressure | 0.55 hPa (20 °C) |
| Viscosity kinematic | 2.14 mm2/s |
| Solubility | 1000 g/l |
| Toxicological Information | |
|---|---|
| LD 50 oral | LD50 Rat 28300 mg/kg |
| LD 50 dermal | LD50 Rat 40000 mg/kg |
| Safety Information according to GHS | |
|---|---|
| RTECS | PV6210000 |
| Storage class | 10 – 13 Other liquids and solids |
| WGK | WGK 1 slightly hazardous to water |
| Disposal | 1 Strongly contaminated halogen-free organic solvents: container A. |
| Storage and Shipping Information | |
|---|---|
| Storage | Store at +2°C to +30°C. |
| Transport Information | |
|---|---|
| Declaration (railroad and road) ADR, RID | Kein Gefahrgut |
| Declaration (transport by air) IATA-DGR | No Dangerous Good |
| Declaration (transport by sea) IMDG-Code | No Dangerous Good |
| Specifications | |
|---|---|
| Assay (GC) | ≥ 99.7 % |
| Identity (IR) | conforms |
| Water | ≤ 0.3 % |
Dimethyl Sulfoxide (DMSO) is a solvent with wide ranging applications in biological research. Dimethyl Sulfoxide (DMSO) can be used as solvent for acetylene, sulfur dioxide and other gases, as an anti-freeze or hydraulic fluid when mixed with water, as a paint or varnish remover and as a solvent for Orlon and other synthetic fibres. Dimethyl Sulfoxide (DMSO) is also used for polymerization and cyanide reactions and in industrial cleaners, pesticides, medicine (anti-inflammatory), veterinary medicine and pharmaceuticals. Dimethyl Sulfoxide (DMSO) (1-10%) has been shown to accelerate strand renaturation and is believed to give the nucleic acid thermal stability against depurination. As a PCR cosolvent, Dimethyl Sulfoxide (DMSO) may help improve yields, especially in long PCR. Dimethyl Sulfoxide is also known as DMSO, Methyl sulfoxide, Dimethyl sulphoxide, and Methylsulfinylmethane.
References
1. Sweat, F.W. and Epstein, W.W. 1967. J. Org. Chem. 32(3): 835-838. PMID: 6042131
2. Chakrabarti, R. and Schutt, C.E. 2001. Gene. 274(1-2): 293-298. PMID: 11675022
3. Pegg, D.E. 2007. Methods Mol. Biol. 368 : 39-57. PMID: 18080461
RTECS :PV6210000
PubChem CID :679
Merck Index :14: 3259
MDL Number :MFCD00002089
EC Number :200-664-3
Beilstein Registry :506008
SMILES :CS(=O)C
