Dimethylacetamide
N,N-Dimethylacetamide (DMAc) is a colorless to yellow liquid with a faint, specific amine-like odor. It is miscible with water and other organic substances. It is a versatile intermediate with a variety of applications for example as solvent.
DMAc is an excellent solvent with high solving power for high molecular-weight polymers and synthetic resins. DMAc is used as a reaction solvent for the manufacture of acryl and polyamide fibres. DMAc is also used for the manufacture of agro chemicals, dyes and pharmaceuticals.
- CAS #: 127-19-5
- Assay (GC, area%) ≥ 99.0 % (a/a)
- EC Number: 204-826-4
- Molar Mass: 87.12 g/mol
- Chemical Formula: CH₃CON(CH₃)₂
- Hill Formula: C₄H₉NO
Description
N,N-Dimethylacetamide
Formula:C4H9NO
InChI:InChI=1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
InChI key:InChIKey=FXHOOIRPVKKKFG-UHFFFAOYSA-N
SMILES:O=C(N(C)C)C
Synonyms:
- 2-Methylpropanamide
- Acetamide, N,N-dimethyl-
- Acetdimethylamide
- Acetic acid dimethylamide
- Acetyldimeethylamine
- Cbc 510337
- Ch3Con(Ch3)2
- DMA
- Dimethyl Acetamide
- Dimethylacetamid
- Dimethylacetamid N,N-
- Dimethylacetamide
- Dimethylacetoneamide
- Dimethylamid kyseliny octove
- Dimethylamide acetate
- Dimetilacetamida N,N-
- Dimetilacetammide N,N-
- Diméthylacétamide, N,N-
- Dmaa
- Dmac
- Essigsaeure-Dimethylamid
- N,N’-ジメチルアセトアミド
- N,N-Dimethylacetamid
- N,N-Dimethylacetamide,(DMA)
- N,N-Dimethylethanamide
- N,N-Dimetilacetammide
- N,N-dimetilacetamida
- Nsc 3138
- Propylene Chloride
N,N-Dimethylacetamide
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.93700 @ 25.00 °C. |
| Melting Point: | -18.59 °C. @ 760.00 mm Hg (est) |
| Boiling Point: | 165.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 1.800000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 3.01 ( Air = 1 ) |
| Flash Point: | 158.00 °F. TCC ( 70.00 °C. ) |
| logP (o/w): | -0.770 |
| Soluble in: | |
| water, 1.00E+06 mg/L @ 25 °C (exp) | |
| water, 5.747e+005 mg/L @ 25 °C (est) | |
What is Dimethylacetamide (CAS: 127-19-5) ?
Dimethylacetamide (CAS: 127-19-5) is a water-miscible organic compound in the form of a colourless liquid with an odour similar to ammonia. This compound is a member of the high boiling point acetamide class.
Dimethylacetamide (CAS: 127-19-5) is commonly used as a polar solvent in organic synthesis.
In 2011, Dimethylacetamide (CAS: 127-19-5) was recognized by the EU as a substance of very high concern (SVHC) due to its reproductive and fertility toxicity.
In addition, in 2014, this compound has been investigated for restriction of use in the EU under REACH. In addition to its reproductive toxicity, it is also an irritant for skin, eyes or inhalation.
Occupational exposure to Dimethylacetamide in excess of 400mg/kg body weight per day may have effects on the central nervous system.
Packaging
| Product Information | |
|---|---|
| CAS number | 127-19-5 |
| EC index number | 616-011-00-4 |
| EC number | 204-826-4 |
| Hill Formula | C₄H₉NO |
| Chemical formula | CH₃CON(CH₃)₂ |
| Molar Mass | 87.12 g/mol |
| HS Code | 2924 19 00 |
| Physicochemical Information | |
|---|---|
| Boiling point | 165 – 166 °C (1013 hPa) |
| Density | 0.94 g/cm3 (20 °C) |
| Explosion limit | 1.7 – 11.5 %(V) |
| Flash point | 64 °C |
| Ignition temperature | 400 °C |
| Melting Point | -20 °C |
| pH value | 4 (200 g/l, H₂O, 20 °C) |
| Vapor pressure | 2 hPa (21.7 °C) |
| Solubility | >1000 g/l soluble |
| Toxicological Information | |
|---|---|
| LD 50 oral | LD50 Rat 5830 mg/kg |
| Safety Information according to GHS | |
|---|---|
| Hazard Pictogram(s) | |
| Hazard Statement(s) | H312 + H332: Harmful in contact with skin or if inhaled. H319: Causes serious eye irritation. H360D: May damage the unborn child. |
| Precautionary Statement(s) | P202: Do not handle until all safety precautions have been read and understood. P280: Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P302 + P352 + P312: IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313: IF exposed or concerned: Get medical advice/ attention. |
| Signal Word | Danger |
| RTECS | AB7700000 |
| Storage class | 6.1C Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 2 obviously hazardous to water |
| Safety Information | |
|---|---|
| Categories of danger | irritant, toxic for reproduction, harmful |
| Storage and Shipping Information | |
|---|---|
| Storage | Store below +30°C. |
| Specifications | |
|---|---|
| Color according to color reference solution Ph.Eur. | colorless liquid |
| Assay (GC, area%) | ≥ 99.0 % (a/a) |
| Density (d 20 °C/ 4 °C) | 0.940 – 0.942 |
| Water (K. F.) | ≤ 0.30 % |
| Identity (IR) | passes test |
Product Categories
Chemistry
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Chemical BiologyPeptide ChemistrySolvents and Mixtures for Peptide Synthesis
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Pharmaceutical Development and Drug Discovery Research ReagentsPeptide ChemistrySolvents and Mixtures for Peptide Synthesis
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SolventsSolvents (Others)
Life Science
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Pharmaceutical Development and Drug Discovery ResearchPeptide ChemistrySolvents and Mixtures for Peptide Synthesis
Chemical properties
Hazard Information
H312+H332: Harmful in contact with skin. Harmful if inhaled.
H319: Causes serious eye irritation.
H360D: May damage the unborn child.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313: If eye irritation persists: Get medical advice/attention.
